Multiple BizTalk application instances with different configuration

Is it possible to run the two biztalk application instances having pointed to different Databases at receive port.

Example: If BizTalk application is BTSApps, having one reciev location pointed to Database.

I want the two instances of biztalk application runs like BTSAppsInstance1 there recive location pointed to DB1.

and BTSAppsInstance2 there recive location pointed to DB2.

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